On the ViaRhôna (765 km from Saint-Gingolph to Sète) the main enemy in summer is heat, not wind, so the best time is September and October, with 75% and 77% good days. In July, an average of 36% of days along the route reach 30 °C, in August 33%. South and north, however, live by different calendars. On the stage Avignon → Sète, 54% of July days are hot, and the best month there is March (84%). On the first stage, Saint-Gingolph → Valleiry, there are only 6% of such days in July.
Downstream or upstream on the Rhône
On average a tailwind gives you almost nothing: 1.0 km/h towards Sète in October. The difference shows up in strong wind. A headwind above 15 km/h hits a northbound rider in the face in 9–12% of hours, a southbound rider in 3–6%. On the Le Pouzin → Avignon stage, in the best month, a tailwind pushes you south at 4.0 km/h. If you do choose a direction, make it towards Sète. The numbers describe the climate of 2006–2025, not a forecast; check the forecast before setting off.